Not sure if you have seen this article about a 4 cylinder Duc or not. If it's old news, my apologies.
Four Cylinder Ducati Superbike Ready In 2017 | Motorbike Only
Four Cylinder Ducati Superbike Ready In 2017 | Motorbike Only
Engines come in many configurations, leaving aside singles, triples and sixes; for 2 cylinder bike engines there are vee twins, parallel twins and opposed twins; 4 cylinder bike engines can be inline, square four and vee four.
The most popular configurations for both are vee twin and inline four, both have pros and cons the main one being that all internal combustion engines are limited in the amount of power they can produce by the number of times a piston can travel up and down per minute (revolutions per minute or rpm), the limiting factors are heat and stress to the moving parts, particularly the con-rods and bearings. The lighter a piston you can fit the less stress it passes on, so for two engines of identical capacity the one with the four (lighter) pistons can move faster and more frequently, turning the engine quicker and making more power than one with two pistons since they would have to displace twice the amount of space per piston. The problem with this is a four cylinder engine makes more heat (almost 70% of an internal combustion engine's power is lost through heat), because the cylinders have to be grouped it becomes more difficult to cool them and still remain compact enough to fit in a motorcycle frame (which is why there are and have been only a few 6 cylinder bike engines). A twin cylinder engine, therefore, makes less power - because it cannot rev as high as a four but is slightly easier to cool (whether by air or liquid), which is how a Ducati vee (or L) twin is able to remain fairly competitive with an inline 4, (that and a capacity increase).
At a riding level the difference is really felt pulling out of a corner or from a standstill, where a twin is generally superior because of a lower spread of torque.
There are a number of other factors that affect an engine, the duration, size and number of valves, the bore and stroke of a piston etc. etc. which makes it almost impossible to make sweeping generalizations.