@ CaliDuc - If by wrist fatigue you mean something like carpal tunnel type discomfort, then sure, a crampbuster or similar product can help - certainly worth a try, since they're cheap, easy to come by and easy to get on and off. I have one, and use it occasionally - generally just when I'm going to be doing a long day that includes a good bit of freeway riding. Throw it on for the transit to the fun zone, then toss it under the tail until it's time for the return leg.
If the issue is too much weight on your hands, then that's down to pure ergonomics - how You fit on Your Bike. Yeah, gripping the tank with your knees will help as will tank pads, but they're really just bandaids as far as wrist pressure is concerned. The true problem is that you're off-balance. Most sportbikes do not have adjustable ergonomics, but while all stock Panigales are built the same and have the same rider triangle, all Panigale riders are not and do not. If while sitting on the bike in a normal riding position, you have to exert much muscular tension to stay there when you let go of the bars, then you need to change something to tweak your CG. We all have a "personal" CG that our brains will always be trying to put us in sync with (on the bike or off) and if we're off balance not only are we going to be uncomfortable, we're not going to have the best control of the bike. So proper position is not just a comfort issue, it's a performance issue as well. Anyone telling you to just suck it up and deal with it is wasting your time.
Of course, moving your contact points on a bike (Pani included) means buying parts, which it shouldn't. Look at a KTM RC8R for an example of how it should be. Significantly adjustable bar height and sweep, adjustable rearsets and an adjustable subframe height & seat position. IMHO there's no good excuse for all manufacturers not offering as much. I mean really; would we accept cars that came with an unmoveable seat and fixed seat/wheel/pedal relationship? Of course not; most of us would immediately recognize that as ridiculous, but we somehow fail to see the same thing as such with motorbikes.
Just because a bike fits someone else out of the box doesn't mean it fits you. Get yourself "centered" and you'll be more comfortable and go quicker as well.