Use a drill press is a must!!!! Start with new small (smallest you can go) drill bit with spray of CRC/WD40, slow and steady wins the race, then move up to the size you require. If you are drilling on a thread like the axle end, I use to put an old nut on and wind it off after drilling (also good if securing in a portable vice), this cleans the thread up before it damages the original when winding it back on, and/or use a thread file/ or die to do this. On the bolt heads, drill press again as it has a flat surface with it secured in a portable vice and drill not to close to where it tapers as it could break when torqueing it down. I had a mate that worked on the Britten V1000 many years ago and his job was to lighten every bolt on the bike, he spent months on a lathe drilling the centres out of the titanium bolts and doing lock wire holes, he got exceptionally good at doing this process, they were just a few things he told me.
Good luck and hope this helps.
I just looked at the pic and the lock wire is looped over the bolt which has a recessed end in this particular case, if you have room, you could file a small flat surface on the bolt end where you require the locking wire to go, just an after thought.