My POV is that it depends on the type of riding you enjoy, and given the opportunity different horses for different courses is best. At the same time, I had the following a few years ago:
A Buell XB9SX, only about 80 rwhp but about the best city bike because of the flat torque curve and super-quick steering (awesome noise too):
A Buell Ulysses that my wife says was the most comfortable bike she's ever ridden on. Still super-quick steering and fun torque, waterproof Hepco & Becker bags held a surprising amount of groceries, got 50+ mpg and could run all day/night:
Buell 1125R - astoundingly competent, with telepathic handling, almost the perfect street sportbike and great liquid-cooled V-Twin power:
MV Agusta F4 1000R - Astoundingly fast, uncomfortable unless riding at 8/10+, capable of serious lap times on track (much to my surprise), and noise to cause "eargasms" (this one is so beautiful it deserves 2 pictures)
Now after having kids I can only have one, and since I love all kinds of riding, but still like being somewhat competitive on track, the 1199 is the latest-greatest and I love it.
But as I find less and less time for racing and track days, I might be able to get all my jollies and be kinder to my ageing bones on just one bike. Something that has almost all the above attributes, super-quick telepathic handling, soulful motor sounds, sophisticated electronics, exotic appeal and maybe just a bit more comfort than the 1199, even though she is pretty comfy: