So the software for TC, lean abs, etc is all based off of real time sensors and has no predictive tables in it? I've seen some discussions on other forums for bikes with high end electronics and some have predictive tables (for example, factory does testing and knows how much torque is delivered in each gear for each throttle opening and uses that partially to predict if an issue is going to occur to augment what is happening in real time). If anything like this is happening in the software, then changing the gearing will affect the electronic systems performance in helping you ride quicker. Of course, if this is the case, anything that affects the stock bikes performance would have an effect on the electronic helpers.
The bike uses the multi axis IMU but on the Ducati’s single sided bikes all of the sensors for speed are on the hub side. As far as overall TCU we have tire calibration I would imagine every thing else would be handled by the IMU. They may be better experts that can answer.