No smarty here; was just a competitive cyclist for over 20 years. In that sport, it's common knowledge that no matter how great a bike you have, unless you get your ergos dialed from the outset, you (and embarrassingly, your new $10K, electronic shifting carbon fiber wonderbike) are going.to.suck.
The power transmission aspects of position don't apply here of course; thankfully, my Pani makes much more power than me (even if it won't run on beer & twinkies). However, the balance and handling aspects most definitely transfer. Here, just like there, we're supporting ourselves with our hands, feet, and butt, and where those contact points are relative to each other, and how we spread our weight between them will either have us centered and balanced or not. For a more moto-relevant, if non-technical view, have a look:
Motorcycle Ergonomics with Blake Young and Chuck Warren of Yoshimura Suzuki - YouTube
Note that when they're talking about comfort, what they're really talking about is feeling balanced and natural, not cozy and coddled - an athletic comfort. What you find is that your position, here just as in cycling, is unique to YOU, and not so much the bike. Reach to the bars from the saddle, their height, width and angle, relative footpeg placement, etc. is something that once you figure out, should be memorized and basically transferred from bike to bike. Teams will keep specs for riders and transfer them to new bikes, and experienced riders who change teams will know what they want their new bike set up like.
At the sharp end, once race teams have that triangle down for the rider, they'll manipulate the whole thing around to affect the bike's loaded center of mass to get the handling optimized; changing tank shapes, subframe positions, etc. I remember when Elena Myers demo'ed the Rizla MotoGP Suzuki a few years back, she was freaking that they were asking her which tank shape and subframe she wanted, just the same as with her bars and rearsets. This is exactly like cycling, where whole frames are either chosen or custom-built to get the overall loaded weight distribution and center of mass vs wheelbase desired for optimum handling. Very important there, where the whole bike weighs less than three gallons of gas.
That's not super critical for street or trackday motorbike riders of course, where we are mostly just looking for a natural feel and lack of problems, but where you sit on the bike will definitely affect how it handles. For example, taller, heavier riders will get much more weight shift than smaller, lighter ones, etc.
Bottom line is that spending some time getting yourself balanced and "comfortable" on the bike will pay easily as much or more dividend as any suspension work you might do.