Panigale V4S: 2021 vs 2024

Pinwheel · 2025-01-17T12:32:20-0800

I've been considering buying either a used '21 V4S or '24 V4S.

1) Were there any issues with the '21 model year for the V4S -- any things I should look out for?

2) What would be the main differences between the '21 and '24 V4S? Differences in the engine? Differences in the electronics and rider aides?

Thanks in advance!

BP PanigaleV4S · 2025-01-17T13:28:19-0800

There were changes in 2022, 2023 2024. Each model year sees changes. Bigger in 2022, less so in 2023 and 2024.

I suggest watching review videos of those model years to get an idea of the changes over the years.

In the V4 Panigale models, 2020, 2022 and 2025 probably saw the biggest changes.

In the US, 2021 was the last year for EU4 emissions, 2022+ is EU5 but outside of that there wasn't really ever a revision to the engine. Gearing (transmission) at some point. The water pumps suck on all of them. Really the only big issue with the V4.

baggerman · 2025-01-17T14:37:48-0800

I think the 22's and later got all the serious changes. Substantial ergonomics changes, they revised the rear header so it cooks you less, swingarm pivot was raised, expansion of riding modes, revised transmission, revised front subframe, 2nd rev of both the water and oil pumps. But then you get Euro 5 as BP mentions. Personally if I were flush with cash it would be a 2025.

SuperDomestique · 2025-01-17T17:40:45-0800

21 is probably about $20k. 22 is about $24k. 25 is $34k.

22 was “a second faster” on track than the previous generation. And the 25 is again “a second faster” than the 24. 25 is marginal gains considering the price difference. 21 → 22 is $4k/sec. 22 → 25 is $10k/sec.

Also don’t forget about bottom ends more than occasionally lunching themselves. But this issue may be sorted now that we know that 300V’s rapidly thinning viscosity is probably the main culprit. Running a more stable oil like Redline or Maxima seems to be the solution.

DV4 · 2025-01-17T18:23:52-0800

SuperDomestique said:
21 is probably about $20k. 22 is about $24k. 25 is $34k.

22 was “a second faster” on track than the previous generation. And the 25 is again “a second faster” than the 24. 25 is marginal gains considering the price difference. 21 → 22 is $4k/sec. 22 → 25 is $10k/sec.

Also don’t forget about bottom ends more than occasionally lunching themselves. But this issue may be sorted now that we know that 300V’s rapidly thinning viscosity is probably the main culprit. Running a more stable oil like Redline or Maxima seems to be the solution.

In the hands of professional riders assisted by the marketing department! My question is what tires were they on (tire tech has also moved on considerably), what were track conditions like, what phase of the moon? I would take the Ducati hype with a grain of salt and accept they have improved the bike but for most "normal" owners the laptime bottleneck is definitely not the bike.

Get the 24 unless the 21 is a real bargain. You can add the R swingarm pivot and get the 21 remapped which gets you pretty much in the ballpark of the 24. The stock Ohlins are ok on both but really need to be upgraded if you start chasing 1/10ths

BP PanigaleV4S · 2025-01-17T18:42:13-0800

Honestly, I'd take the one that has an exhaust and tune on it.

Pinwheel · 2025-01-17T19:08:05-0800

Thanks for all the info, everyone! The '21 is tempting at just under a 20K asking price. It's all stock with no upgrades or mods, and is a one owner bike. Dealer informed me that I could still get EverRed warranty on it for a 3-year duration.

BP PanigaleV4S · 2025-01-17T19:27:42-0800

All stock has great benefits as no one has bolted a bunch of farkles to it. How many miles?

Panigale V4S: 2021 vs 2024

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