Aside from the closed-loop issue, the Panigale is difficult to attach wide-band O2 sensors. You can see a dyno set-up (Tuneboy's) on the Akro full system thread Post #108. The adapter on the rear pipe is an Innovate adapter to go from 12mm to the 18mm wide-band, the adapter on the front is from Bay Area Performance Cycles in Mountain View Calif.
And aside from the closed-loop and sensor mounts the system has trim tables for both cylinders and each gear, so your Power Commander map works differently in each gear.
On top of that, the throttle progressivity tables make it very difficult to tune because you can't just hold a throttle position and do a run. For any twist grip setting the throttle angle changes with RPM.
In short, PCV is more than kinda difficult to tune and that defeats the quick and effective aspect.