We tried to get Multistrada hard-luggage mounted, but the velcro just wouldn't hold it.
Having lived on the Panigale for 6 months, my recommendation is:
The Kriega bags come with lots of different straps giving you a lot of different options. Here's how I mounted mine...
Rear:
Use one single rear strap to secure the rear of the bag (using the the lic. plate holder arm thing as the mount). See pics below.
Front:
Remove your rear seat (or solo cowl) and you'll see two allen bolts securing the seat lock. These bolts are what I used to hard-mount two straps in the trunk. Simply remove the one on the left and bolt the end of a Kriega strap down. Then repeat for the right (I used slightly longer bolts).
(Here's what the end of the Kriega strap looks like)
Benefits:
1) Lots of storage space (full size laptop, charger, plus a lot of clothes).
2) The hard-mount straps can be stored under the seat (out of sight) when you're not using the bag.
3) Takes 30 sec. to mount or remove bag
4) Filling up w/petrol doesn't require removal (aka tank bag)
5) Provides a nice little hump to rest a backpack on to relieve stress from your shoulders.
Kriega US-20 motorcycle bag
Here's a pic (near the Tail of the Dragon on a nice sunny day) where you can see how it mounts at the rear:
And this shows you how clean the front mount is: