Panigale V4S: 2021 vs 2024

I've been considering buying either a used '21 V4S or '24 V4S.

1) Were there any issues with the '21 model year for the V4S -- any things I should look out for?

2) What would be the main differences between the '21 and '24 V4S? Differences in the engine? Differences in the electronics and rider aides?

Thanks in advance!

There were changes in 2022, 2023 2024. Each model year sees changes. Bigger in 2022, less so in 2023 and 2024.

I suggest watching review videos of those model years to get an idea of the changes over the years.

In the V4 Panigale models, 2020, 2022 and 2025 probably saw the biggest changes.

In the US, 2021 was the last year for EU4 emissions, 2022+ is EU5 but outside of that there wasn't really ever a revision to the engine. Gearing (transmission) at some point. The water pumps suck on all of them. Really the only big issue with the V4.

I think the 22's and later got all the serious changes. Substantial ergonomics changes, they revised the rear header so it cooks you less, swingarm pivot was raised, expansion of riding modes, revised transmission, revised front subframe, 2nd rev of both the water and oil pumps. But then you get Euro 5 as BP mentions. Personally if I were flush with cash it would be a 2025.

21 is probably about $20k. 22 is about $24k. 25 is $34k.

22 was “a second faster” on track than the previous generation. And the 25 is again “a second faster” than the 24. 25 is marginal gains considering the price difference. 21 → 22 is $4k/sec. 22 → 25 is $10k/sec.

Also don’t forget about bottom ends more than occasionally lunching themselves. But this issue may be sorted now that we know that 300V’s rapidly thinning viscosity is probably the main culprit. Running a more stable oil like Redline or Maxima seems to be the solution.

SuperDomestique said:

21 is probably about $20k. 22 is about $24k. 25 is $34k.

22 was “a second faster” on track than the previous generation. And the 25 is again “a second faster” than the 24. 25 is marginal gains considering the price difference. 21 → 22 is $4k/sec. 22 → 25 is $10k/sec.

Also don’t forget about bottom ends more than occasionally lunching themselves. But this issue may be sorted now that we know that 300V’s rapidly thinning viscosity is probably the main culprit. Running a more stable oil like Redline or Maxima seems to be the solution.

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In the hands of professional riders assisted by the marketing department! My question is what tires were they on (tire tech has also moved on considerably), what were track conditions like, what phase of the moon? I would take the Ducati hype with a grain of salt and accept they have improved the bike but for most "normal" owners the laptime bottleneck is definitely not the bike.


Get the 24 unless the 21 is a real bargain. You can add the R swingarm pivot and get the 21 remapped which gets you pretty much in the ballpark of the 24. The stock Ohlins are ok on both but really need to be upgraded if you start chasing 1/10ths

Honestly, I'd take the one that has an exhaust and tune on it.

Thanks for all the info, everyone! The '21 is tempting at just under a 20K asking price. It's all stock with no upgrades or mods, and is a one owner bike. Dealer informed me that I could still get EverRed warranty on it for a 3-year duration.

All stock has great benefits as no one has bolted a bunch of farkles to it. How many miles?

I own a 2022 V4S, my first Ducati and purchased used. My research suggested that the biggest change was between 21 and 22. The 22 and newer has a longer 1st gear, but with little experience with older models. The information I interpret again suggests newer models have incrementally better improvements, this will never stop, so where do you draw the line? I will never be able exploit the real full potential of my bike or any other Ducati V4 and think any good condition well kept V4 of recent years, one could not go wrong if your not a hard core GP rider, so as long as the condition is good, and a recent year any Ducati is a fun choice, but if you can afford or justify it, I suggest the newer model. Some advice, the exhaust is the only performance mod I would do as it reduces lots of weight, but stay away from exotic mapping which I did and regretted the ridiculous snappy uncontrollable performance, the bikes stock are sick and with exhaust, it quite a hand full. What ever you get have fun.

BP PanigaleV4S said:

All stock has great benefits as no one has bolted a bunch of farkles to it. How many miles?

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4700 miles on it.

Check the dates on the tires. Pretty low miles for a 21.